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Singh, Rajat
- Review on the Formulation Considerations Needed to Produce a Stable Self Micro Emulsifying Drug Delivery System (SMEDDS)
Abstract Views :179 |
PDF Views:1
Authors
Ashok Chandrakar
1,
Bishesar Sahu
1,
Homendra Sahu
1,
Jagdish Dewangan
1,
Navin Kumar
1,
Rajat Singh
1,
Rohit Gupta
1,
Devesh Kumar
1,
Bhishm Sahu
1,
Kuldeep Dewangan
1,
Rishi Kaushal
1,
Mukta Agrawal
1,
D. K. Tripathi
1,
Ajazuddin
1,
Amit Alexander
1
Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh 490024, IN
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh 490024, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 5 (2017), Pagination: 1563-1570Abstract
Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs with minimum dose. Although many formulation approaches like solid dispersions, complexation, pH modifications and lipid based delivery systems finding increased appliance with the apparent increase in absorption of drug. Among lipid based formulations, self-micro emulsifying formulations (droplet size < 100 nm) are evident to improve the oral bioavailability of hydrophobic drugs primarily due to their efficiency in facilitating solubilization and in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented. Various components that are used to formulate these dosage forms like surfactants and lipids contribute to the overall improvement in oral bioavailability via promoting the lymphatic transport; thereby hepatic first pass metabolism can be surmounted. The present article gives exhaustive information on the formulation design and characterization of SMEDDS by which the bioavailability can be improved. In this review article, the various aspects of pharmaceutical SMEDDS where compiled together and target audience are specifically the B.Pharm and M.Pharm students so that their knowledge towards the subject concern can be enhanced and also at the same time can be motivated towards the publication.Keywords
SMEDDS, Solubilization, Emulsion, Stability, Surfactant.- Effect of Different Drying Technique on the Bioactive Components of Terminalia arjuna Bark
Abstract Views :157 |
PDF Views:0
Authors
Affiliations
1 Amity Institute Biotechnology, Amity University, Rajasthan, Jaipur, IN
1 Amity Institute Biotechnology, Amity University, Rajasthan, Jaipur, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2372-2378Abstract
In this study the effect of four different drying techniques such as sun drying, oven drying, microwave drying and freeze drying of Terminalia arjuna bark have been studied. The effectiveness of different drying technique was measured in terms of phytochemical screening, total phenol, flavonoid, alkaloid and protein content. The antioxidant activity and antimicrobial activity were also determined. In phytochemical screening revealed the presence of alkaloid, triterpenoid, saponins, glycosides and phytosterols in different dried T. arjuna stem bark extract. The phenol, flavonoid, alkaloid and protein content were highest in freeze dried extract. Then it was followed by microwave, oven and sun dried extract. The antimicrobial activity and antioxidant activity were also found maximum in freeze dried T. arjuna stem bark. Among all sun drying was found most detrimental drying technique for bioactive components of T. arjuna stem bark and freeze drying was best for bioactive components of T. arjuna stem bark.Keywords
Terminalia arjuna, Drying, Bioactive, Antimicrobial Activity.References
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